Weight loss may be a rare side effect of lamotrigine, or Lamictal. In people with bipolar disorder, lamotigine may lead to weight loss among those who are obese, according to a 2006 study published by Charles L. Bowden and colleagues in the American Journal of Psychiatry. Meilleure réponse: I take Lamictal and have had no weight gain at all.It's also one of the best meds I've ever been on. I also have a friend who is on Topamax and she said she has lost weight. I have recently started taking Lamictal for bipolar, 25mg the first week and am now at 50mg until I see my pdoc next month. I have been having trouble eating since starting the lamictal. Most bipolar drugs cause weight gain rather than weight loss. For example, several of them increase your blood sugar level, which can lead to weight gain. If you are taking Lamictal and weight loss occurs, ask your healthcare provider about ways to manage this. An Overview of Lamictal and Weight Loss Lamictal ® ( lamotrigine ) is a prescription medication used to treat bipolar disorder and epilepsy. 30 LAZY LIFE HACKS for WEIGHT LOSS That Actually Work!!! How to Lose Weight Easily Without Trying - Duration: 12:28. Wengie 9,514,292 views If you take Lamictal and have gained weight, it’s unlikely that the drug is the culprit. It’s more likely that the weight gain is an effect of the disorder itself. Bipolar disorder can. From the beginning of my treatment for bipolar disorder, I've struggled with weight gain. Gaining weight has been my most bothersome side effect, with excessive thirst coming in second. I also had weight loss on Lamictal. I lost about 12 pounds in 4 months. I don't feel hungry or I forget to eat (since my lazy memory is also a symptom). As much as people say lucky you, it isn't as great as you might think. I'm already small to begin with so people noticed and kept saying things about it. It's been strange to say the least. In the first clinical trials involving the drug, 5 percent of adults with epilepsy lost weight while taking Lamictal, while between 1 and 5 percent of patients with bipolar I disorder gained weight while on the drug. The researchers didn't disclose how much weight the patients gained or lost.